※ 引述《timothy70417 (绝地武士)》之铭言： 27 下列调控酵素活性的方式，何者为不可逆的（irreversible）？ A 异位调节（allosteric regulation） B 共价修饰（covalent modification） C 酶原（zymogen）的蛋白水解切割（proteolytic clevage） D 非竞争型抑制剂（uncompetitive inhibitor）的结合 答案C 线上的stryer也写到: fructose 1,6-bisphosphatase 是一个allosteric enzyme 他也会造成irreversible的例子 所以建议答案应该是 A或B或C 不知道这样可以吗? 16.3.4. The Conversion of Fructose 1,6-bisphosphate into Fructose 6-phosphate and Orthophosphate Is an Irreversible Step On formation, phosphoenolpyruvate is metabolized by the enzymes of glycolysis but in the reverse direction. These reactions are near equilibrium under intracellular conditions; so, when conditions favor gluconeogenesis, the reverse reactions will take place until the next irreversible step is reached. This step is the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and Pi. The enzyme responsible for this step is fructose 1,6-bisphosphatase. Like its glycolytic counterpart, it is an allosteric enzyme that participates in the regulation of gluconeogenesis. We will return to its regulatory properties later in the chapter. --

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