原先是只打算做个简易版自己看 但有人推荐还是给大家 所以就又PO版了 不过这算是简易中的简易 请不要太挑剔 有些地方写得很鸟就是了 有错烦请指正 感谢 一、 Opioids 1.Morphine: agonist 2.Codeine: agonist, 治疗咳嗽 3.Hydromorphone: agonist 4.Oxymorphone: agonist, used in combination with triflupromazine for neuroleptanalgesia (FDA approved use in dogs & cats) 5.Meperidine: agonist 6.Fentanyl: agonist, used in combination with droperidol for neuroleptanalgesia 7.Etorphine: agonist, wild & exotic speices (FDA), used only when diprenophine or other suitable antagonists are available 8.Buprenorphine: partial agonist for μ receptors 9.Pentazocine (Sosegon): mixed, κ agonist and weak μ antagonist 10.Butorphanol: mixed, κ agonist and weak μ antagonist 11.Nalbuphine: mixed, κ agonist and μ antagonist 12.Nalorphine: mixed, antagonize typical respiratory depression induced by opioids 13.Naloxone: antagonist 14.Diprenorphine: antagonist, reverse etorphine in wild animals 二、 Preanesthetic Medications 1. Anticholinergic 2. Phenothiazine 3. Butyrophenone 4. Benzodiazepine 5. α2-Adrenergic Agonist 6. Opioid 三、 Local Anesthetics 1.Procanie 2.Benzocaine: 鱼 3.Chloroprocaine: 产科 4.Tetracaine 5.Lidocaine: 常用 6.Prilocaine: 过量会methemoglobinemia 7.Bupivacaine: 产科 8.Etidocaine 9.Ropivacaine 四、 Anticonvulsants 1.Phenobarbital: grand mal, partial seizure & status epilepticus, second line 2.Primidone: converted to phenobarbital in vivo 3.Benzodiazepines: absence seizure ,myoclonic seizure & status epilepticus 4.Phenytoin (diphenylhydantoin): Na+ channel blocker, broad spectrum (except absence seizure) but narrow therapeutic window 5.Carbamazepine: Na+ channel blocker, partial seizure 6.Valproic acid: Na+ channel blocker, tonic-clonic, absence, myoclonic& partial seizures, second line 7.Ethosuximide: Reduce Ca+2 currents in thalamic neurons, first line drug for absence seizure 8.Potassium bromide: through chloride channels and hyperpolarizing neurons, first line 五、 CNS Stimulants 1.Ephedrine: nasal decongestant 2.Amphetamine: release NE and DA & block reuptake, 减肥、治疗ADHD 3.Methylphenidate (Ritalin): 治疗ADHD 4.Sibutramine (诺美婷; Reductil): 减肥 5.Orlistat (罗氏纤/鲜 Xenical): 减肥 6.Cocaine 7.Methylxanthine: Caffeine (competitive inhibitor for adenosine A1 receptors), Theophylline(支气管扩张) & Theobromine 8.Nicotine 9.Strychnine: inhibit glycine, induces tonic convulsion 10.Picrotoxin (Picrotoxinin + Picrotin): inhibit GABA, induces clonic and tonic (high dose) convulsion 11.Doxapram: excite brainstem neurons, respiratory analeptic used in dogs, cats and horses (FDA), good safety margin between analeptic dose and convulsant dose, 难产或剖腹产後给新生儿 12.4 Aminopyridine (4 AP): 机制不明 六、 Antidepressants 1.Tyramine: release of stored monoamines 2.Clorgyline: MAO-A inhibitor 3.Selegiline: MAO-B inhibitor, treat pituitary-dependent hyperadrenocorticism (dopamine deficiency) in dogs, and Parkinson’s disease in humans 4.Imipramine: tricyclic antidepressant (TCA), block neuronal reuptake of 5-HT & NE (but not DA) 5.Clomipramine: tricyclic antidepressant, separation anxiety in dogs (FDA) 6.Amitriptyline: tricyclic antidepressant 7.Doxepin: tricyclic antidepressant 8.Paroxetine: SSRI 9.Fluoxetine: SSRI, Prozac 10.Sertraline: SSRI 七、 Autocoids & Antagonists 1.Histamine: 测试气管过敏 2.Pentagastrin: 测试胃酸分泌 3.Betazole: 胃分泌 4.Cromolyn: mast cell stabilizer 5.Nedocromil: mast cell stabilizer 6.Diphenhydramine: first-generation agent 7.Chlorpheniramine: first-generation agent 8.Promethazine: first-generation agent 9.Cyclizine: first-generation agent 10.Terfenadine: second-generation agent 11.Astemizole: second-generation agent 八、 Serotonin & Antagonists 1.Melatonin 2.Buspirone: 5-HT1A agonist, anxiolytic 3.Sumatriptan: 5-HT1B/1D agonist, anti-migraine 4.Cyproheptadine: block 5-HT and H1, 促进食慾 5.Ketanserin: block 5-HT1C/2 and α1, 降高血压 6.Ondansetron: 5-HT3 blocker, 止吐 7.Tropisetron: 5-HT3 blocker, 止吐 8.Granisetron: 5-HT3 blocker 9.Dolasetron: 5-HT3 blocker 10.Cisapride: 5-HT4 agonist, 肠胃道蠕动 --

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