The adult liver is the largest organ and plays a major role in metabolism and has several functions in the body, including detoxification, plasma protein synthesis and so on. The liver consists several types cells that including hepatocytes, Kupffer cells, hepatic stellate cells, sinusoidal endothelial cells, and blood cells. On the other hand, fetal liver is a hematopoietic tissue and acquires metabolic ability with decreasing proliferation, becomes a metabolic organ after birth. This dramatic change triggered by several signal transduction and carrier on specific transcriptional factors. However, the mechanisms of the regulation does not understanding very well. Thus, to understand the regulatory of gene transcription during liver development may provide a good way to discover a new treatment for liver diseases. --------- 敬请指教. --

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