作者hpw01 (hpw)
看板Pharmacy
标题[问题] niacin对HDL的影响
时间Fri Jul 27 15:56:06 2012
书上提到
niacin strongly inhibits lipolysis in adipose tissue—the primary producer of
circulating free fatty acids. The liver normally utilizes these circulating
fatty acids as a major precursor for triacylglycerol synthesis. Thus, niacin
causes a decrease in liver triacylglycerol synthesis, which is required for
VLDL production. LDL (the cholesterol-rich lipoprotein) is
derived from VLDL in the plasma. Therefore, a reduction in the VLDL
concentration also results in a decreased plasma LDL concentration. Thus,
both plasma triacylglycerol (in VLDL) and cholesterol (in VLDL and LDL) are
lowered .
以上看得懂
Furthermore, niacin treatment increases HDL
cholesterol levels.
niacin的治疗会增加HDL的浓度
请问是为什麽呢?
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