大家好 <(_ _)> 来帮我九月即将开幕的实验室打个广告徵人 实验室位於香港大学(University of Hong Kong) 生物医学科学系(School of Biomedical Sciences)https://www.sbms.hku.hk/) 系上的成员很国际化,主要语言是英文 实验室主要是使用重组的人类微管蛋白(recombinant human tubulin) 从生物化学～生物物理及结构生物学的角度 来探讨不同微管蛋白同种型(isotypes)是如何在人体内扮演重要的角色 实验室主要的技术为蛋白质纯化,单分子萤光显微镜(TIRF microscopy),以及冷冻电子显微镜(cryoEM) 博士班学生的话会有全额奖学金 我会帮助你申请香港博士班奖学金(Hong Kong PhD Fellowship) https://cerg1.ugc.edu.hk/hkpfs/index.html 申请HKPDF到的话一个月有两万五千块港币~ 没申请到的话会有两万块港左右(我还要跟系上确认) 同时也欢迎具有生物化学,生物物理及结构生物学背景的来申请博士後或研究助理的职缺 有兴趣者请将简历,代表性论文及推荐信寄到[email protected] 谢谢 详情请看下面英文版的说明 Postdoctoral/Ph.D. Position in Biochemistry and Biophysics Lab of Dr. Shih-Chieh Ti The laboratory of Dr. Shih-Chieh Ti in the School of Biomedical Sciences at the University of Hong Kong (https://www.sbms.hku.hk/) is seeking enthusiastic and self-motivated postdoctoral scientists and Ph.D. students to investigate the underlying mechanism for human tubulin isotypes to regulate the biological function of microtubules. The human genome encodes multiple α- and β-tubulin gene families (i.e., isotypes) that have the protein expression profile varying with cell types and developmental stages. While single point mutations in a specific tubulin isotype have been associated with human diseases, the molecular mechanism by which tubulin isotypes regulate the organization of microtubules remains poorly understood. Through using the field-leading technology to generate isotypically pure recombinant human tubulin, Ti Lab will employ combinatorial approaches of biochemistry, biophysics, chemical biology, and structural biology to investigate the intrinsic properties of different human tubulin isotypes. Please see the following references to learn more on Dr. Ti’s previous work. An ideal candidate should have an excellent experiment and communication skills. Preference will be given to applicants with a strong background in molecular biology, protein purification, and cell culture. Please send (1) your CV, (2) a brief description of research interests and experience, and (3) three confidential letters of reference to [email protected]. 1) Ti, S.C.; Alushin, G.M.; Kapoor, T.M. (2018) “Human β-tubulin isotypes can regulate microtubule protofilament number and stability” Developmental Cell, 47, 175-190. PMID: 30245156. 2) Pamula, M.C.; Ti, S.C.; Kapoor, T.M. (2016) “The structure core of human β tubulin confers isotype-specific polymerization properties” J. Cell Biology, 213, 425-33. PMID: 27185835. 3) Ti, S.C.; Pamula, M.C.; Howes, S.C.; Duellberg, C.; Cade, N.I.; Kleiner, R.E.; Forth, S.; Surrey, T.; Nogales, E.; Kapoor, T.M. (2016) “Mutations in human tubulin proximal to the kinesin-binding site alter dynamic instability at microtubule plus and minus ends” Developmental Cell, 37, 72-84. PMID: 27046833. --

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