Ph.D. Position @ Laboratoire d'Informatique PAris Descartes (LIPADE) 45 rue des Saints-Pères, 75006 Paris Subject: Descriptive modeling of cell populations to assist the diagnosis of biomedical images The objective of this Ph.D. thesis is to propose models and algorithms to capture and describe the interactions between small distinct elements such as cells and fiber structure in biological images. These models reflect part of the behavior between cells, which is a key issue in several pathologies. The context deals with large cell populations mainly observed in histological color images. Various medical problems can be adressed using these images: detection and description of groups of tumor cells, quantitative measures of the correlation between these cell characteristics and their environment such as vascular structures, cell migration modeling in the stromae, measures of the muscular inflammation etc. A first possible investigation will deal with interaction models based on inhibition and proliferation behavior between extracted elements. These models require a good compromise between the number of parameters to include in order to generalize the model and their estimation. Dealing with harder to segment fluoroscopic images, another investigation will be to develop features based on the connected components of the image. A 3D generalization of these representation could be studied. Dealing with interactions between groups of elements, a third investigation track will be the study of quantitative models such as force histograms. This Ph.D. position is part of the SPIRIT project, funded by ANR and starting during fall 2011. This research project gather members from the LIPADE image team, UPCGI (Pharmacology Lab. From Paris Descartes) and Cochin Institute. Some collaborations and internships during the thesis are possible with Ecole Polytechnique de Montreal in the context of other biomedical projects. For this position, candidates should hold a Ms.C. or equivalent with a strong focus on image processing and computer vision. The candidate should also have strong programming and writing skills. The thesis is due to start during fall 2011. For any application (CV + cover letter) or questions, please contact Thomas Hurtut at [email protected] and Laurent Wendling at [email protected] --

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