※ [本文转录自 88-PH 看板] 作者: Hsuanly (笨熊) 看板: 88-PH 标题: [情报] 四月份演讲公告 时间: Mon Apr 7 10:03:57 2003 流病所与预医所联合演讲会通知 时间：92 年 4 月 15 日(星期二) 12：30-13：30 地点：基医大楼 1536 讲堂 主讲人：卢鸿兴 教授 交通大学统计研究所教授兼所长 讲题：Visualization, Screening, and Classification of Cell Cycle-Regulated Genes in Yeast by Multidimensional Scaling, Nonlinear Dimension Reduction and Wavelet 摘要： We propose a new and integrated approach for visualization,screening, and prediction of gene functions using microarray data,based on multidimensional scaling (MDS), nonlinear dimension reduction and wavelet transform. This approached is applied to analyze the cell cycle of yeast in Spellman et al. (1998). The results show that this new approach indeed provides a visualization tool, which displays the functional relationships between genes, like the periodical pattern of a cell cycle. This representation can be further used to verify the functions of genes explored by experimental methods in literature. Based on this epresentation with biological knowledge, screening and prediction of the functions of all genes can be implemented. The performances of different methods in screening and prediction are evaluated by the Jackknife approach in this study. Hence, this integrated approach suggests a new perspective to discover and classify the functions of genes through their expression profiles by microarray. The findings for cell cycle-regulated genes in yeast are also reported and discussed. --

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※ 发信站: 批踢踢实业坊(ptt.csie.ntu.edu.tw) ◆ From: 140.112.120.83