作者Hsuanly (LW)
看板PH-90
标题[情报]六月份演讲讯息
时间Fri Jun 11 11:19:59 2004
※ [本文转录自 PH-89 看板]
作者: Hsuanly (LW) 看板: PH-89
标题: [情报]六月份演讲讯息
时间: Fri Jun 11 11:19:44 2004
流病所与预医所联合演讲会通知
时 间：93 年 6 月 15 日(星期二) 12：30-13：30
地 点：基医大楼 1536 讲堂
主讲人：谢叔蓉 副研究员 (中央研究院 统计科学研究所)
题 目：Reconstructing Gene Networks by A Data-driven Response Surface Method
摘 要：Xu et al. (2000) introduced an interesting response surface model to
reconstruct gene networks from microarray data. However, the fixed
surface approach failed to find meaning Activator-Repressor-Target
Gene triplets in Yeast data sets (Spellman et al., 1998). We proposed
a data-driven response surface model. The innovation is two-fold:
1. the surface is constructed by data and
2. it allows a time-lag for the activator and repressor genes to act
on the target gene.
Using the alpha Yeast data set, part of the networks reconstructed
are consistent with existing biology knowledge. While some novel
parts are yet to be verified by RT-PCR.
Those networks that are consistent with annotated biology knowledge
are as follows: RAD50 represses SGS1 SOD1 activates TOP1, SAE2
represses RAD51 and rAD51 in turn represses RAD24 and RAD54 represses
RAD24.
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