Intern Seminar考题 First Part VS 简颖秀 by Ri林其懋 (E) 1. 关於唐氏症的叙述，下列何者为非 (A) 唐氏症病患除了会有智能障碍，发展迟缓的问题以外，还可能会有过动，具攻 击性等行为问题，以及重度忧郁等心理问题 (B) 几乎所有唐氏症病患到了成年(30-40岁)都会有类似Alzheimer disease的神经 病变 (C) 唐氏症病患刚出生的时候，脑子结构跟正常婴儿并没有明显的差异。智能障碍 的发生主要是因为在成长的过程中，脑部逐渐发生退化的缘故 (D) Chromosome 21上的q22区域被认为跟许多唐氏症病患的许多特徵(如智能障碍， 先天性心脏病，特殊脸型)很有相关。 (E) 以上皆对 (E) 2. 关於唐氏症智能障碍的治疗，下列何者为非 (A) 非特异性治疗方面包括营养治疗，荷尔蒙治疗，和早疗。早疗对智力发展的帮 助不大，但对运动技能和社交能力有一定程度的帮忙 (B) Acetylcholinesterase inhibitor可以提升脑中的Acetylcholine；Selective serotonin-reuptake inhibitor可以提升脑中的serotonin，两者都有助於唐 氏症病患脑部的发育 (C) 过量的glutamine刺激会过度活化NMDA receptor，对神经细胞产生毒害，因此 NMDA antagonist有助於减少唐氏症病患脑部的破坏 (D) Minocycline和COX-2 inhibitor可以减缓唐氏症病患脑中过强的发炎反应，减 少脑部的破坏，达到保护的目的 (E) 以上皆对 (E) 3. 关於神经性疾病的基因治疗，下列何者为非 (A) Adenovirus，adenoassociated virus，lentivirus，以及liposomes是最常用 的载体，可以将基因带入神经细胞中 (B) Lentivirus是RNA virus，它引发的宿主免疫反应很小，但却有致癌的可能性 (C) Adenovirus是DNA virus，它会引发较强的宿主免疫反应，因此比较没办法让转 过去的基因长期表现 (D) Adenoassociated virus是DNA virus，不同的serotype喜欢感染不同的神经细 胞，例如AAV5喜欢感染小脑的Purkinje cells而不会感染granular cells (E) 以上皆对 (E) 4. 关於RNA interference，下列何者为非 (A) RNA interference是一种用来抑制特定基因表现的技术，它把特定基因的double -stranded RNA homologous打入细胞中，就能有效抑制抑制特定基因的表现 (B) 这种技术最早是1998年在C. Elegans上发现的。本来以为无法用在哺乳类细胞上 面，但後来发现只要将dsRNA缩小成21-22 nucleotides (称为 small interfer- ing RNA, siRNA)就能避免哺乳类细胞对dsRNA产生免疫反应，从而应用在哺乳类 细胞上 (C) 科学家将siRNA做成fold-back stem-loop的结构，称为short hairpin RNA(shRNA )，可以大大加强该技术抑制基因表现的时间和稳定度 (D) 利用RNA interference来抑制唐氏症病患过量的基因表现，是未来治疗唐氏症的 一个方向 (E) 以上皆对 Second Part VS 杨曜旭: by Ri 陈银君 (B) 1.There are many health benefits from lactobacillus or Bifidobacterium in recent studies. Which is NOT reported formally in the following choices? (A) preventing irritable bowel syndrome (B) curing cancer (C) reducing atopic dermatitis (D) enhance bacteria clearance of lung. (D) 2.In the article “oral treatment with life Lactobacillus reuteri(LR) inhibits the allergic airway response in mice”, which choice is NOT noted? (A) circulatory eosinophils can be reduced after LR added (B) OVA + LR reduce airway inflammation (C) Treatment of LR significantly attenuated the increase in MCP-1, TNF, IL-5 and IL-13. (D) heat-killed or gama-irradiated LR also can modulate airway inflammation response. (A) 3. In the article “oral treatment with life Lactobacillus reuteri(LR) inhibits the allergic airway response in mice”, which choice is NOT including in attenuating allergic airway response? (A) L. salivarians (B) LR (C) TLR-9 (D) IDO activation. By Ri 蔡万全 (A) Which of the following is false? A. The preventive effect of probiotics on infant eczema was well established and no further research was needed. B. An altered microbial exposure may be partly responsible for the increase of allergic diseases in populations with a western lifestyle. C. Probiotics have been reported to improve the symptoms in infants with eczema in a recent study. D. Different probiotic strains might have different properties critical for an effect on allergic diseases. By Ri 林奕辰 (A) 1. 关於“A live microbial food supplement with a proved beneficial effect on human health.” 是以下何者的定义？ (A) probiotic (B) prebiotic (C) antibiotic (D) antipsychotic (B) 2. 怀孕期至婴儿早期，婴儿体内cytokine是以下列何者为主？ (A) TH1 humoral immune (B) TH2 humoral immune (C) TH3 humoral immune (D) 以上皆非 (D) 3. 下列何者非probiotic？ (A) Bifidobacterium longum (B) Bifidobacterium infantis (C) Lactobacillus rhamnosus (D) E. coli (D) 4.大部分肠道菌丛以下列哪一种receptor与肠道epithelium interaction？ (A) complement receptor (B) chemokine receptor (C) hormone receptor (D) Toll like receptor (C) 有关 ”Hygiene hypothesis” 及probiotic的临床研究中证实，给予probiotic可减少哪一种atopic disease的发生？ (A) asthma (B) allergic rhinitis (C) atopic eczema (D) food allergy Third Part VS 陈慧玲: By Ri 陈宜明 (e) 1.Which statement is wrong about Alagille syndrome? a. A dominant inherited multisystem disorder b. The incidence is 1 per 100,000 live births c. Involved mutations in Jagged1 gene d. The phenotype presentation shows a great variety in severity e. Liver transplantation is indicated in a majority of patients (b) 2.Which of the following descriptions is not common characteristics of Alagille syndrome? a. Bile duct paucity b. Broad forehead; deep-set, widely-spaced eyes; and an over-developed mandible c. Posterior embryotoxon d. Peripheral stenosis of the pulmonary artery e. Butterfly-like vertebral-arch defects (b) 3. Which statement is wrong about liver transplantation in children with Alagille syndrome? a. Clear criteria are difficult to establish in clinical practice b. Post-op complications included acute graft rejection, vascular complications, Infections, ascites, diaphragmatic hernia, and hypercholesterolemia c. Common vascular complications included portal vein thrombosis, mid-aortic syndrome, and arterial bleeding. d. There were more post-transplant bleeding complications in patients with Alagille syndrome than in those with other diagnosis e. Control post-transplant arterial hypertension carefully or performing preoperatively angiographic evaluations can prevent bleeding complications. By Ri 叶芷圻 (D) 1. Algille's syndrome ( arteriohepatic dysplasia ) 下列哪个不正确? A) Intrahepatic bile duct atresia B) JAG1 gene mutation C) D-bilirubin升高 D) 大便颜色正常, 可以和biliary atresia区分 (A) 2. Extrahepatic biliary atresia 的孩子手术术式应该选择: A) Kasai operation B) Cesarean section C) Orchypexy D) Blalock-Taussig Shunt (C) 3. Ectrahepatic biliary atresia 开完刀的预後和下列何者比较无关? A) bile stasis的程度 B) inflammation process C) EKG的finding D) JAG1 mutation 的有无 --

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