课程名称︰讯息传递与疾病 课程性质︰选修 课程教师︰主授陈青周（此范围为陈青周/蔡丰乔/李明学老师授课） 开课学院：医学院 开课系所︰医卫共同课程 考试日期（年月日）︰2017/04/14 考试时限（分钟）：110分钟 试题 : (以下叙述均非与原题目完全相同，仅就考试主题作最接近之题目描述) 陈青周老师part：占20分 (范围：Introduction: Basics of cell signaling) 问答题： Please describe the receptor tyrosine kinase pathway and its relation to cancer cells. (20%) (加分题的概念，有时间请尽量发挥) ---------- 蔡丰乔老师part：占30分 (范围：GPCR signaling pathways + Second messengers) 一、选择题：2题，各2分，均是问下列何者叙述错误 1. 叙述错误为 "The biggest population in the GRAFS system of GPCR is the Frizzled GPCR." 2. 叙述错误为 "PKA can be inactivated by the combination of cGMP." 二、是非题：6题，各1分，题干叙述正确的居多 ＊ 有一题考Cholera toxin的致病机转，题干叙述"Gαs protein持续活化造成efflux of chloride ions and leads to secretion of H2O into the intestinal lumen." 应该是正确的 (因为上课没讲很仔细) 三、简答题：共20分 1. Please list three examples of second messengers that impress you the most. Why? (6%) 2. Please list three features of GPCR signaling pathway that impress you the most. Why? (6%) 3. Please list two regulators of GPCR signaling pathway that impress you the most. Why? (4%) 4. Please list two molecules in the Ca2+ signaling pathway that impress you the most. Why? (4%) ＊ 简答题题目均附有以下三点说明： (The item and reason will be one score respectively.) (Please summarize your answers in two lines. The answers outside the two lines will not be scored.) (You can give any examples including but not limited to their structures, functions, regulations, possible therapies or related drugs) ---------- 李明学老师part：占60分 (范围：RTK + Ras proteins + MAPK pathway + oncogenes/TSGs) 简答题： 1. Please list out at least four reasons that will make the receptor tyrosine kinase EGFR constitutively active. (8%) 2. What are the molecular mechanisms of Src activation? What is the Src mutation in virus that will cause the sarcoma? (8%) 3. What are the five members in the Ras family? (5%) 4. What are the molecular mechanisms from GDP-associated Ras to GTP-associated Ras? (5%) 5. Why does the mutation G12D in Ras make it become constitutively active? (5%) (考前提醒有提到mutation会造成影响，但上课+讲义中找不到...Orz) 6. How does MEK1/2 activate ERK1/2? What are the two groups of proteins regulated by ERK1/2? (8%) (答案似乎是转录因子TCF与RSF，很容易忽视带过的地方) 7. What is the function of the MAPK scaffold proteins? (7%) 8. What are the possible reasons for proto-oncogenes to become oncogenes? Please list out at least four possibilities. (8%) 9. If BRCA1 or BRCA2 gains loss-of-function mutations in both of its allele, is there any possible therapeutic strategy to target this kind of cancer cells? (6%) ---------- 以上总分共计110分 --

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