课程名称︰分析化学丁 课程性质︰药学系 医学检验暨生物技术学系 必修 课程教师︰张焕宗 开课学院：理学院 开课系所︰化学系 考试日期（年月日）︰March 26, 2014 考试时限（分钟）： 180分钟 是否需发放奖励金： 是 （如未明确表示，则不予发放） 试题 : I. Comparison: (21 pts, 3 pts each) (II) Buffer (9pts, 3 pts each): (III) Acid and base: (15 pts; 6 pts for (1), 3 pts each for the rest) (IV) Solubility (6 pts, 3 pts each) (V) Absorption (21 pts, 3 pts each) (VI) Calculation (9 pts, 3 pts each) (VII) Standard addition method (9 pts, 3 pts each) (VIII) Methodology (9 pts, 3 pts each) (IX) Drug analysis (12 pts; 6 pts for (2), 3 pts for the rest) Atorvastatin calcium (ATR) is mainly used for lowering blood cholesterol, while ezetimibe (EZ) is used for the treatment of hypercholesterolemia and homozygous sitosterolemia. Combination of ATR and EZ has the advantages of greater therapeutic effects than with either drug alone. This combination causes manifold reduction in LDL cholesterol level as compared to double dose of the individual drug when used alone. Moreover, using of EZ with ATR enhances the effects of statins at lower dose and reduces the associated side effects. The UV-vis spectra for ATR (solid curve) and EZ (dotted curve) are shown below. (1) Why is it advantageous of using a cmobination of the two drugs over individual? (2) Suggest a spectrometric method for the determination of the contents of the two drugs in a pure mixture containing the two drugs. (3) Is sample pretreatment necessary for the determination of the concentrations of the two drugs in blood samples prior to the spectrometric analysis? Why? --

※ 发信站: 批踢踢实业坊(ptt.cc), 来自: 123.241.32.165 ※ 文章网址: http://webptt.com/cn.aspx?n=bbs/NTU-Exam/M.1404293226.A.C9C.html ※ 编辑: yungye (123.241.32.165), 07/07/2014 17:54:14