If the day arrives when you are in graduate school when you wake up and do not wish to jump out of bed and head off to lab, it is time to consider whether it is time to switch to another lab. I have encountered many students who realized midway during their PhD that they were not happy in their lab, only to decide to stick it out rather than discuss the situation with their advisors and try to resolve the problem. My advice is to have a heart-to-heart chat with your advisor, giving him or her a chance to help you resolve the issue. If your advisor is not sympathetic, then it is time for you to switch to another lab. If you cannot find a lab that you are happy in, then it is possible that science is not the right career for you. But all too often, the problem is simply poor mentoring or a mismatched lab for whatever reason. I have seen all too many students feel that they must please their advisors and complete their projects. But always remember that your PhD training is about YOU and your success. Most productivity occurs in the last 1 or 2 years of a PhD thesis and usually switching to a new lab, even after a few years in the wrong lab, does not delay a student’s graduation. Just think of your time in the first lab as a long rotation that beneficially added to your training. ref:https://doi.org/10.1016/j.neuron.2013.10.005 -- 你是从几时开始忘记了？ 忘记这辈子其实很长，长到你可以跌倒再站起来，作梦又醒过来； 你又是从几时开始忘记了， 这辈子其实很短，短得你没时间再去勉强自己，没时间再去讨厌你自己。 从现在开始，从这里开始，不要再忘记了 --

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