作者Ice98 (又寂寞又美好)
看板NEMS
标题[分享] 让PDMS变成亲水性的方法
时间Tue May 27 20:46:09 2008
最近做了一点功课, 在此与大家分享
[PDMS的亲疏水性]
PDMS has repeating uints of –OSi(CH3)2- groups. This chemical structure
leads to a hydrophobic surface.
Exposing this surface to an air or oxygen plasma introduces silanol (Si-OH)
groups, destroys methyl groups (Si-CH3), and makes the surface hydrophilic.
PDMS that has been treated with plasma can be kept hydrophilic indefinitely
by keeping the surfaces in contact with water or polar organic solvents.
Otherwise, If the surface is left in contact with air, surface rearrangements
occur that bring new hydrophobic groups to the surface to lower the surface
free energy.
Ref:
J. N. Lee, C. Park and G. M. Whitesides, “Solvent compatibility of
poly(dimethylsiloxane)-based microfluidic devices”, Anal. Chem., Vol. 75,
2003, pp. 6544-6554
[Method 1] Extraction
1. Immerse in an extremely soluble solvent, diisopropylamine (DIPA), to extract
the soluble components from cross-linked PDMS.
2. Immerse in ethyl acetate (1 day) and acetone (2 days) and then dry in a 90°C
oven for 2 days.
3. Oxygen plasma treatment.
Ref:
J. N. Lee, C. Park and G. M. Whitesides, “Solvent compatibility of
poly(dimethylsiloxane)-based microfluidic devices”, Anal. Chem., Vol. 75,
2003, pp. 6544-6554
[Method 2] Sog-Gel Modification
1. PDMS were solvated in tetraethyl orthosilicate (TEOS), causing them to
expand. (TEOS is potentially hazardous, and appropriate precautions should be
taken when using it)
2. Placed in an aqueous solution containing 2.8% ethylamine.
3. Rinse with ultrapure water.
4. Place in an oven at 95°C for 1 h to form nanometer-sized SiO2 particles
within the cross-linked PDMS polymer.
Ref:
G. T. Roman et al., “Sol-gel modified poly(dimethylsiloxane) microfluidic
devices with high electroosmotic mobilities and hydrophilic channel
wallcharacteristics”, Anal. Chem., Vol. 77, 2005, pp. 1414-1422
[Method 3] Plasma-Induced Grafting
1. Bath with diethyl ether and acetone.
2. Rinse with detergent solution and DI water.
3. Argon and hydrogen plasma treatment.
4. Immerse into acrylonitrile solution for 4 h.
5. Rinse with acetone, ethanol, detergent solution and DI water.
6. Dry at 100°C for 1 h.
Ref:
Q. He et al., “Preparation of hydrophilic poly(dimethylsiloxane) stamps by
plasma-induced grafting”, Langmuir, Vol. 19, 2003, pp. 6982-6986
[Method 4] Modify with HEMA
1. Oxygen plasma treatment.
2. Spin coat 2-hytdroxy ethyl methacrylate (HEMA).
3. Oxygen plasma treatment.
Ref:
D. S. Bodas and C. Khan-Malek, “Fabrication of long-term hydrophilic
surfaces of poly(dimetheyl sioxane) using 2-hydroxy ethyl methacrylate”,
Sensors and Actuators B, Vol. 12, 2007, pp. 719-723
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1F：推 eagleman:推 常用的方法 可用来bonding PDMS 05/27 20:52
2F：→ Ice98:请问楼上的 哪种比较好用ㄚ =.=a 05/27 21:42
3F：推 eagleman:我们是打氧电浆 05/27 21:43
4F：→ Ice98:只打氧气电浆好像撑不到一天... Orz 05/27 21:50
5F：推 oactioner:氧电将打完要泡水里面 才能称比较多天 05/27 21:51
6F：→ oactioner:pdms泡盐酸也有亲水性效果 但好像不会超过1星期 05/27 21:53
7F：→ pinlittle:ps一下..如果要养细胞,可以先coat一层ECM molecule.. 05/27 22:02
8F：推 largesperm:打 ICP 6 秒 ... 再把两片 PDMS 合在一起就行了 05/27 22:56
9F：→ largesperm:放太久还是会变回疏水性的 05/27 22:57
10F：→ pinlittle:我忽然想到...我们为何不换种材料...干嘛一定什麽都要 05/27 23:12
11F：→ pinlittle:PDMS...然後再那边想办法改质搞的要死... 05/27 23:12
12F：→ pinlittle:我承认我有点疯...但我们要是找到另一种不错的材料 05/27 23:13
13F：→ pinlittle:不也是一篇好文章~~~ 05/27 23:13
14F：推 oactioner:NOA63好像可以取代 有PAPER 05/27 23:19
15F：→ oactioner:Simple Route to Hydrophilic Microfluidic Chip 05/27 23:20
16F：→ oactioner:Fabrication Using an Ultraviolet (UV)-Cured Polymer 05/27 23:20
17F：→ yanzichiro:之前我们买了一台电晕的仪器 05/30 00:38
18F：→ yanzichiro:只用仪器在其表面上扫过几秒 放入烤箱 05/30 00:39
19F：→ yanzichiro:可以完全接合 那台仪器是可以PORTABLE的 挺方便 05/30 00:40
20F：推 Jinuse:楼上说的是corona discharging 好用但是不适用在导电物体 05/30 02:05
21F：→ Jinuse:我们之前有拿PDMS去试看看 但是因为下面有导电层会让他短路 05/30 02:06
22F：推 MicroOptics:我的疑问是亲水性和疏水性对PDMS的最大影响为何 06/14 20:31
23F：推 peter33:如果PDMS後续制程需与玻璃等表面具亲水性质的材料结合 07/16 11:01
24F：→ peter33:把PDMS用O2 plasma使其也具亲水性会比较适合 07/16 11:03
25F：推 roguematt:请问电晕的仪器可以让PDMS与PMMA接合吗?接合後PDMS里有 09/09 14:49
26F：→ roguematt:微流道，里面通水，通水後会让接合失效吗? 09/09 14:51