题 目: Sample Size Determination for Testing Equality in a Cluster Randomized Trial with Noncompliance 主讲人: Professor Kung-Jong Lui (Department of Mathematics and Statistics, San Diego State University) 时 间: 100年6月3日（星期五）上午 10:40 - 11：30 （上午10：20- 10：40茶会於统计所821室举行） 地 点: 清大综合三馆837室 Abstract For administrative convenience or cost efficiency, we may often employ a cluster randomized trial (CRT), in which randomized units are clusters of patients rather than individual patients. Furthermore, because of ethical reason or patient’s decision, it is not uncommon to encounter data, in which there are patients not complying with their assigned treatments. Thus, the development of a sample size calculation procedure for a CRT with noncompliance is important and useful in practice. Under the exclusion restriction model, we have developed an asymptotic test procedure using transformation for testing equality between two treatments among compliers for a CRT with noncompliance. We have further derived a sample size formula accounting for both noncompliance and the intraclass correlation for a desired power at a nominal level. We have employed Monte Carlo simulation to evaluate the finite-sample performance of the proposed test procedure with respect to Type I error and the accuracy of the derived sample size calculation formula with respect to power in a variety of situations. Finally, we use the data taken from a CRT studying vitamin A supplementation to reduce mortality among preschool children to illustrate the use of sample size calculation proposed here. 敬请公布 欢迎参加 --

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