题 目: Estimate the Occurrence Rate of the DNA Palindromes 主讲人: 杜忆萍 博士 (中研院统计所) 时 间: 100年4月1日（星期五）上午 10:40 - 11：30 （上午10：20- 10：40茶会於统计所821室举行） 地 点: 清大综合三馆837室 Abstract A DNA palindrome is a segment of double-stranded DNA sequence with inversion symmetry which may form secondary structures conferring significant biological functions ranging from RNA transcription to DNA replication. To test if the clusters of DNA palindromes distribute randomly is an important bioinformatic problem, where the occurrence rate of the DNA palindromes is a key estimator for setting up a test. The most commonly used statistics for estimating the occurrence rate for scan statistics is the average rate. However, in our simulation, the average rate may double the null occurrence rate of DNA palindromes due to hot spot regions of 3000 bp’s in a herpes virus genome. Here, we propose a formula to estimate the occurrence rate through an analytic derivation under a Markov assumption on DNA sequence. Our simulation study shows that the performance of this method has improved the accuracy and robustness against hot spots, as compared to the commonly used average rate. In addition, we derived analytical formula for the moment-generating functions of various statistics under a Markov model, enabling further calculations of p-values. This is a joint work with Yuan-Fu Huang and Shao-Hsuan Wang. 敬请公布 欢迎参加 --

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