※ [本文转录自 NTHU_STAT96 看板] 作者: allen1985 (我要低调 拯救形象) 看板: NTHU_STAT96 标题: 演讲公告 时间: Tue Oct 2 16:52:09 2007 清华大学、交通大学 统 计 学 研 究 所 专 题 演 讲 题 目: The Effects of Population Stratification and Misclassification in Studies of Gene-Environment Interactions 主讲人: 郑光甫教授 (中国医药大学生物统计中心) 时 间: 96年10月12日（星期五）10：40 - 11：30 （上午10：20-10：40茶会於统计所821室举行） 地 点: 清大综合三馆837室 Abstract Population stratification (confounding by ethnicity) and misclassification of genotype may cause the usual tests in case-control studies producing spurious gene-disease associations. To control for the resulting bias, several powerful approaches have been proposed using unlinked markers. However, the effects of population stratification and misclassification of genotype and environmental exposure in studies of gene-environment interactions are still not clear. In this paper, we quantify the effects of population stratification and misclassification in case-control and case-only studies under general conditions. We also present two conditions under which the effect of population stratification and/or misclassification does not exist in case-control or case-only studies of gene-environment interactions. The two conditions are: (1) genotype and environmental exposure are conditionally independent given stratification variable, and (2) environmental exposure and stratification variable are conditionally independent given genotype. We conducted a simulation study, using parameter values from real examples, to compare the performance of different tests for gene-environment interactions. Our results show that under the given simulation conditions, case-only approach for studying gene-environment interactions is the most powerful method, which is not only insensitive to population stratification and misclassification but also has the best performance in power. 敬请公布 欢迎参加 --

※ 发信站: 批踢踢实业坊(ptt.cc) ◆ From: 125.226.160.158 --

※ 发信站: 批踢踢实业坊(ptt.cc) ◆ From: 140.113.114.214