12/3感染与免疫 何老师会先上课 之後再讨论paper和几个问题， Immunity to Burkholderia pseudomallei (Curr Op Infect Dis 2009, 22 :102-108) (will be discussed on 12/3) http://tinyurl.com/yle9f4s 但是上课前老师希望大家先把答案找出来，题目如下 1. What is B. psudomallei? What diseases does it cause? Have there been outbreaks of malioidosis in Taiwan? 2. What is the virulence mechanism of this organism (virulence factors? Roles of these virulence factors in pathogenesis?)? How to study? 3. What is the host defense against this pathogen? How to study? 4. What are the most important implications or potential applications of these findings? 老师上课时会抽问大家 另外还有回家作业，看paper Mechanism of avoidance of host immunity by Neisseria meningitides and its effect on vaccine development (Lancet Infect Dis 2009, 9: 418-427) (will be left as homework to be handed in by 12/17) http://tinyurl.com/yj3csn6 同样要回答问题，12/17之前缴交纸本，约1~3页，题目如下， 1. How can this organism inhabit the human body? 2. Why has the development of vaccines against serogroup B been a major challenge? How has this problem been solved? 3. What new concepts or pieces of knowledge have you learnt from this paper? 4. Any different opinions or prospects? 就酱，大家辛苦了 --

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