※ [本文转录自 Gossiping 看板] 作者: nikeman (nikeman) 看板: Gossiping 标题: Re: [讨论] 有关於贺宝芙的事吗? 时间: Fri Sep 21 21:54:38 2007 ※ 引述《apa9394 (委员长老虎)》之铭言： : 最新一期的肝病学期刊登出来说Herbalife的几样产品有肝毒性的报告 是人的... : 是瑞士的医院发的 : 这个期刊在肝病学领域是排第3的 IF4点多... : 很多人在猜是indication的问题 尚在厘清中 : http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17692989&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum : http://0rz.tw/0536F : J Hepatol. 2007 Oct;47(4):521-6. Epub 2007 Jul 24. : Herbal does not mean innocuous: Ten cases of severe hepatotoxicity associated : with dietary supplements from Herbalife((R)) products.Schoepfer AM, Engel A, : Fattinger K, Marbet UA, Criblez D, Reichen J, Zimmermann A, Oneta CM. : University Hospital of Bern, Gastroenterology Clinic, Bern, Switzerland. 草本并不能和无毒划上等号。有10件严重的肝毒素病例是来自服用贺宝芙的减重产品。 (然後是研究者的名字: 一堆瑞士人) : BACKGROUND/AIMS: Herbal agents are popular and perceived as safe because they : are supposedly 'natural'. We report 10 cases of toxic hepatitis implicating : Herbalife((R)) products. METHODS: To determine the prevalence and outcome of : hepatotoxicity due to Herbalife((R)) products. A questionnaire was sent to all : public Swiss hospitals. Reported cases were subjected to causality assessment : using the CIOMS criteria. RESULTS: Twelve cases of toxic hepatitis implicating : Herbalife((R)) preparations (1998-2004) 现在的草本的代餐食品非常流行，大多数人都认为它们是"天然"的而吃得很安心。 我们呈报10件和贺宝芙产品相关的肝炎中毒案例。 方法: 为确定肝毒素的普遍程度以及病灶乃来自贺宝芙产品，所有瑞士境内的公立医院 将会收到相关问卷。呈报的案例将由 CIOMS 的标准进行病患评估。 (CIOMS = council for international organizations of medical sciences www.cioms.ch) : were retrieved, 10 sufficiently documented to permit causality analysis. : Median age of patients was 51 years (range 30-69) and latency to onset was 5 : months (0.5-144). Liver biopsy (7/10) showed hepatic necrosis, marked : lymphocytic/eosinophilic infiltration and cholestasis in five patients. : One patient with fulminant liver failure was successfully transplanted; the : explant showed giant cell hepatitis. Sinusoidal obstruction syndrome was : observed in one case. Three patients without liver biopsy presented : with hepatocellular (2) or mixed (1) liver injury. Causality assessment of : adverse drug reaction was classified as certain in two, probable in seven and : possible in one case(s), respectively. CONCLUSIONS: We present a case series : of toxic hepatitis implicating Herbalife((R)) products. Liver toxicity may be : severe. A more detailed declaration of components and pro-active role of : regulatory agencies would be desirable. 结果: 12件肝炎性中毒的案例指向病因为贺宝芙的产品配方出了问题。而有10件完整的 病例报告允许我们作进一步分析。大多数的病患是中年人，岁数从30至69岁不等，平均 年龄为51岁。肝病毒潜伏期平均有5个月。有5个病例的肝组织切片显示出肝坏疽，淋巴 球嗜红润透，以及胆汁阻塞。1个病例有猛爆性肝衰竭，已经完成肝脏移植；此例的肝切 片出现巨大的细胞性肝炎。其中有一例出现肝窦状隙阻塞症候群。有三例缺少肝切片的 病患出现肝脏膨胀脱出，或混合性肝损伤。由逆向施药测试的病例评估分成三类，各为 两名、七名、与一名病例。 结论: 我们所呈现的肝毒素病案例病因指向贺宝芙的产品。肝脏中毒可以是非常严重的。 更详细的食品内容标示，以及管理良好的直销商能否扮演好具前瞻性的脚色，是贺宝芙必 须加强执行的。 --- 若有误请指正 医学用语请相关科系加注 我之前去贺氏早餐店吃了快半年 现在觉得非常害怕说 --

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