ptt2 作者 lookdog (小高狗) 看板 dogandcat 标题 [资料] 关键字礼来 ~~Ractopamine瘦肉精 时间 Sun Apr 1 06:03:08 2012 ─────────────────────────────────────── 关键字 Lilly Ractopamine toxic 777. Ractopamine (WHO Food Additives Series 31) http://www.inchem.org/documents/jecfa/jecmono/v31je09.htm RACTOPAMINE First draft prepared by Dr L. Ritter Bureau of Veterinary Drugs Health Protection Branch Health and Welfare Canada, Ottawa .... 2.3 Observations in humans A pilot clinical trial evaluating bronchodilator activity of ractopamine in oral dosage form and as aerosol was conducted in 1960. Ractopamine was administered orally to four patients with chronic bronchial asthma at doses of 30 and 45 mg. No clear-cut evidence of bronchodilator activity, CNS stimulation, or increase in pulse rate was seen in these patients. Two patients receiving 30 to 45 mg of ractopamine showed 15 to 20 mm Hg systolic elevation of blood pressure lasting for about 1 h. A summary on the use of 50 mg/ml ractopamine with a DeVilbiss nebulizer in four asthmatic patients indicated that on a 0 to 4 scale of effectiveness according to patients, ractopamine scored 3, 3, 1 and 0 in these patients. It was stated that ractopamine as an aerosol has failed to show any activity at doses up to 6 mg (Shipley, 1960). ..... 3. Human data - A survey of all non-therapeutic effects that follow long-term ß-adrenoceptor agonist use in humans, to assist in the prediction of the consequences of the long-term intake of residues of ractopamine by consumers of animal meat. Depending on the results of the above investigations, it may be necessary to perform other studies to explore further the potential carcinogenicity of ractopamine ..... 5. REFERENCES DALIDOWICZ, J.D. (1986a). Metabolism of 14C-ractopamine HCl in the rat. Unpublished Report No. ABC-0285 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. DALIDOWICZ, J.D. (1986b). Metabolism of 14C-ractopamine HCl in the dog. Unpublished Report No. ABC-0301 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. DALIDOWICZ, J.D. & BABBITT, G.E. (1986). Characterization of 14C residues in tissues and excreta from swine fed 14C-ractopamine HCl. Unpublished Report No. ABC-0355 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. DALIDOWICZ, J.E., THOMSON, T.D. & HERBERG, R.J. (1986). 14C-ractopamine HCl balance - excretion study in swine. Unpublished Report No. ABC-0330 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. DALIDOWICZ, J.D. (1987). Comparative metabolism of 14C-ractopamine HCl in swine, dogs, and rats. Unpublished Report No. ABC-0369 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. SHIPLEY, R.E. (1960). Summary for research project committee May 31, 1960. Unpublished memoranda from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D. & THOMPSON, C.Z. (1984). The effect of compound 31537, EL-737 on the induction of bacterial mutation using a modification of the Ames test. Unpublished Report No. 840507GPA2000 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., NEGILSKI, D.S. & MARKEY, T.F. (1984a). The acute dermal, ocular, and inhalation toxicity of compound 31537 (EL-737). Unpublished Reports Nos. B-D-82-84, B-E-108-84 and R-H-47-84 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., HILL, L.E. & PROBST, G.S. (1984b). The effect of compound 31537, EL-737, on the induction of DNA repair synthesis in primary cultures of adult rat hepatocytes. Unpublished Reports Nos. 840503UDS2000 and 840508UDS2000 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., REXROAT, M.A. & PROBST, G.S. (1984c). The effect of EL-737 (compound 31537) the induction of reverse mutations in Salmonella typhimurium using the Ames test. Unpublished Report No. 840716AMS2000 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., OBERLY, T.J., BEWSEY, B.J. & PROBST, G.S. (1984d). The effect of 31537 (EL-737) on the induction of forward mutation at the thymidine kinase locus of L517Y mouse lymphoma cells. Unpublished Report No. 840627MLA2000 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R., BRIDGE, T.L. (1985a). The acute toxicity of compound 31537 (EL-737) administered orally to the ICR mouse. Unpublished Reports Nos. M-0-178-84 and M-0-179-84 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R. & BRIDGE, T.L. (1985b). The acute toxicity of compound 31537 (EL-737) administered orally to the Fischer 344 rat. Unpublished Report No. R-0-132-84 and R-0-133-84 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R. & BRIDGE, T.L. (1985c). The acute toxicity of compound 31537 (EL-737) administered intraperitoneally to the Fischer 344 rat. Unpublished Reports Nos. R-P-08-84 and R-P-09-84 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R. & BRIDGE, T.L. (1985d). A three-month toxicity study of ractopamine hydrochloride fed in the diet to B6C3F1 mice. Unpublished Report No. M01584 from Lilly Research Laboratories, Division of Eli Lilly and Company Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R. & BRIDGE, T.L. (1985e). A three-month toxicity study of 031537 (EL-737) administered orally to Fischer 344 rats. Unpublished Report No. R06184 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R. & BRIDGE, T.L. (1985f). 8-Day inhalation study in rhesus monkey. Unpublished Report No. P06288 from Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R. & BRIDGE, T.L. (1985g). 18-Day inhalation study in rhesus monkey. Unpublished Report No. P00388 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R., & BRIDGE, T.L. (1985h). An interim summary of a 6-week subchronic toxicity study of ractopamine hydrochloride administered by nasogastric gavage to rhesus monkeys. Unpublished Report No. P00691 from Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly, and Company, Indianapolis, IN, USA. WILLIAMS, G.D., McKINLEY, E.R., & BRIDGE, T.L. (1985i). The effect of subchronic administration of ractopamine hydrochloride on heart rate and electrocardiographic waveforms in conscious rhesus monkeys. Unpublished Report No. P02186 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., NEAL, S.B. & PROBST, G.S. (1985j). The effect of compound 31537 (EL-737) on the in vivo induction of sister chromatid exchange in bone marrow of Chinese hamsters. Unpublished Report No. 850121SCE2000 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., NEGILSKI, D.S. & BRIDGE, T.L., MARKEY, T.F. (1985k). The acute oral, dermal, ocular and inhalation toxicity of a granular premix formulation (AFN-026) containing 10% compound 31537 (EL-737). Unpublished Reports Nos. R-0-188-85, B-D-104-85, B-E-120-85, and R-H-066-85 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., HOYT, J.A. (1986). An eleven-month two-generation reproduction study, including a teratology segment, in Cd rats maintained on diets containing ractopoamine hydrocholoride (EL-739, Compound 31537). Unpublished report for study Nos. R11385 and R18985 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., (1987a). Comparative bioavailability of 14C-ractopamine hydrochloride (031537, EL-737) following a single oral dose of 0.125 mg/kg in the dog and monkey. Unpublished Reports Nos. D04686 and P03086 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D., (1987b). A chronic toxicity study of ractopamine hydrochloride administered orally to beagle dogs for one year. Unpublished Report No. D05885 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. WILLIAMS, G.D. & POHLAND, R.C. & BYRD, T.K. (1987). Bioavailability of radiocarbon following the administration of single oral doses of 14C-EL-737 (31537) to F344/N Hsd BR rats. Unpublished Reports Nos. R03985, RO4085 and RO4185 from Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana, USA. Submitted to WHO by Elanco Products Company, Division of Eli Lilly and Company, Indianapolis, IN, USA. See Also: Toxicological Abbreviations Ractopamine (WHO Food Additives Series 53) RACTOPAMINE (JECFA Evaluation) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 於2005毕台大药学系 小高 高静涵 研毕一年 从农化转过去的 我只是随便找找ㄟ 太扯了吧 -- 歌词网志 streetvoice http://tw.streetvoice.com/profile/home.asp?sd=680163 --

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