这篇论文真的是我看过作machine learning少数可以准确率超过九成的. 但文章写是因为 他们有众多受试者, 约两百人, 比平常实验多六七倍左右. 但我是觉得这个结果还是too good to be true. 有些emotion的meta analysis加一加受试者也上百人, 但仍然呈现很大 的分歧在. 这结果有点令人吃惊就是了. -- 网址: http://tinyurl.com/pvh3gj2 http://medicalxpress.com/news/2015-08-brain-signature-human-emotions.html?hoot PostID=ca74f9096b871dd06f1a7791b416fd92 论文: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002180 -- Researcher discovers 'brain signature' that predicts human emotions A Dartmouth researcher and his colleagues have discovered a way to predict human emotions based on brain activity. The study is unusual because of its accuracy—more than 90 percent—and the large number of participants who reflect the general adult population rather than just college students. The findings could help in diagnosing and treating a range of mental and physical health conditions. The study appears in the journal PLOS Biology. "It's an impressive demonstration of imaging our feelings, of decoding our emotions from brain activity," says lead author Luke Chang, an assistant professor in Psychological and Brain Sciences at Dartmouth. "Emotions are central to our daily lives and emotional dysregulation is at the heart of many brain- and body-related disorders, but we don't have a clear understanding of how emotions are processed in the brain. Thus, understanding the neurobiological mechanisms that generate and reduce negative emotional experiences is paramount." The quest to understand the "emotional brain" has motivated hundreds of neuroimaging studies in recent years. But for neuroimaging to be useful, sensitive and specific "brain signatures" must be developed that can be applied to individual people to yield information about their emotional experiences, neuropathology or treatment prognosis. Thus far, the neuroscience of emotion has yielded many important results but no such indicators for emotional experiences. In their new study, the researchers' goals were to develop a brain signature that predicts the intensity of negative emotional responses to evocative images; to test the signature in generalizing across individual participants and images; to examine the signature's specificity related to pain; and to explore the neural circuitry necessary to predict negative emotional experience. Chang and his colleagues studied 182 participants who were shown negative photos (bodily injuries, acts of aggression, hate groups, car wrecks, human feces) and neutral photos. Thirty additional participants were also subjected to painful heat. Using brain imaging and machine learning techniques, the researchers identified a neural signature of negative emotion—a single neural activation pattern distributed across the entire brain that accurately predicts how negative a person will feel after viewing unpleasant images. "This means that brain imaging has the potential to accurately uncover how someone is feeling without knowing anything about them other than their brain activity," Chang says. "This has enormous implications for improving our understanding of how emotions are generated and regulated, which have been notoriously difficult to define and measure. In addition, these new types of neural measures may prove to be important in identifying when people are having abnormal emotional responses - for example, too much or too little— which might indicate broader issues with health and mental functioning." Unlike most previous research, the new study included a large sample size that reflects the general adult population and not just young college students; used machine learning and statistics to develop a predictive model of emotion; and, most importantly, tested participants across multiple psychological states, which allowed researchers to assess the sensitivity and specificity of their brain model. "We were particularly surprised by how well our pattern performed in predicting the magnitude and type of aversive experience," Chang says. "As skepticism for neuroimaging grows based on over-sold and -interpreted findings and failures to replicate based on small sizes, many neuroscientists might be surprised by how well our signature performed. Another surprising finding is that our emotion brain signature using lots of people performed better at predicting how a person was feeling than their own brain data. There is an intuition that feelings are very idiosyncratic and vary across people. However, because we trained the pattern using so many participants - for example, four to 10 times the standard fMRI experiment—we were able to uncover responses that generalized beyond the training sample to new participants remarkably well." More information: Chang LJ, Gianaros PJ, Manuck SB, Krishnan A, Wager TD (2015) A Sensitive and Specific Neural Signature for Picture-Induced Negative Affect. PLoS Biol 13(6): e1002180. DOI: 10.1371/journal.pbio.1002180 --

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