※ 引述《wangea (射鵰)》之铭言： : 补上参考答案: : 41.(D) 好像高血压比较严重(http://www.goohi.net/viewthread.php?tid=148) : HPA axis 抑制一般於停药後会立即恢复，也许比较次要吧 : 42.(C) 共笔P14. : 43.(D) (http://www.uptodateonline.com/online/content/topic.do?topicKey : =minmetab/14899#2) : 有说越低剂量越好 不是很确定要不要选以上皆非(因为补钙药物补充也很重要) : 44.(E) : 45.(D) : 46.(E) (http://www.tccf.org.tw/medecine/nm_25.htm) ABCD是对的 E是错的 : 47.(C?) (http://en.wikipedia.org/wiki/COX-2_inhibitor) : Cox-2-selectivity does not seem to affect other adverse-effects of : NSAIDs (most notably an increased risk of renal failure), : 不过在(UPTODATE: Overview of selective COX-2 inhibitors ) : 和(COX-2 selective inhibitors: Adverse cardiovascular effects) : 使用COX-2亦有肾衰竭的危险 The effects of selective COX-2 inhibitors on renal function and blood pressure are attracting increasing attention. In the kidney, COX-2 is constitutively expressed and is highly regulated in response to alterations in intravascular volume. COX-2 metabolites have been implicated in the mediation of renin release, regulation of sodium excretion, and maintenance of renal blood flow. Similar to nonselective NSAIDs, inhibition of COX-2 may cause edema and modest elevations in blood pressure in a minority of subjects. COX-2 inhibitors may also exacerbate preexisting hypertension or interfere with other antihypertensive drugs. Occasional acute renal failure has also been reported. Caution should be taken when COX-2 inhibitors are prescribed, especially in high-risk patients (including elderly patients and patients with volume depletion). 总而言之COX-2 inhibitor 跟　NSAID都会造成GFR下降 : 48.(E) (http://www.rheumatology.org.tw/edu_b.htm) : 49.(B) 属於NSAID : 50.(D) : --- : 不一定对...好像很多都没教过 : 请大家参考罗 --

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