P13 框框内的Ethanol改成Methanol 小标题的Formepizole改成Fomepizole p14 普拿疼在肝中代谢"需要"GSH的帮助 P19 第一行 基因通过细胞"膜"是基因治疗的速率决定步骤 Q:有人问到喝到甲醇对人体造成伤害的到底是甲醛还是甲酸？ A: Methanol is toxic by two mechanisms. Firstly, methanol (whether it enters the body by ingestion, inhalation, or absorption through the skin) can be fatal due to its CNS depressant properties in the same manner as ethanol poisoning. Secondly, in a process of toxication, it is metabolised to formic acid (which is present as the formate ion) via formaldehyde in a process initiated by the enzyme alcohol dehydrogenase in the liver. The reaction to formate proceeds completely, with no detectable formaldehyde remaining. Formate is toxic because it inhibits mitochondrial cytochrome c oxidase, causing the symptoms of hypoxia at the cellular level, and also causing metabolic acidosis among a variety of other metabolic disturbances. Fetal tissue will not tolerate methanol. 所以是甲"酸"，他会抑制细胞色素C氧化酶，造成细胞缺氧的症状，也会造成acidosis。 补充： 甲醇中毒的话补充叶酸可以促进甲酸的排泄！ ------------------------------------------------------------------------------ 有其他问题可以再跟我联络~ 祝大家药理考试顺利~! --

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