Metabolic Alkalosis Administration of Diuretics (Except the Carbonic Anhydrase Inhibitors) All diuretics cause increased flow of fluid along the tubules, usually increasing flow in the distal and collecting tubules. This leads to increased reabsorption of Na+ from these parts of the nephrons. Because the sodium reabsorption here is coupled with H+ secretion, the enhanced sodium reabsorption also leads to an increase in H+ secretion and an increase in bicarbonate reabsorption. These changes lead to the development of alkalosis, characterized by increased extracellular fluid bicarbonate concentration. Gyuton 12e pp.392 --

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