※ 引述《colulu ( )》之铭言： > 如题 > 咖啡因在人体的讯息传递pathway中是不是有明确的途径? > 小弟上网找了很久 都没有比较完善的资料 > 但是基本的神经传递理论先前有建立好 > 只是不太晓得咖啡因上瘾和神经、讯息传递上的明确关系 > 希望各位大得提供见解 感恩感恩^^ 除了下面说的pathway外, 咖啡因可能也抑制mTOR pathway (in vitro), 另外印象中记得有些酵素需要咖啡因当cofactor. http://www.STKE.org Sci. STKE, Vol. 2002, Issue 146, pp. tw303, 20 August 2002. [DOI: 10.1126/stke.2002.146.tw303] NEUROBEHAVIOR: Coffee, Caffeine, and DARPP-32 Caffeine is a well-known psychostimulant that increases motor activity by inhibiting the action of the neuromodulator adenosine. By binding to adenosine receptors (A1 and A2A) present in inhibitory neurons in the brain, caffeine prevents activated A2A receptors from initiating a signaling pathway that triggers cAMP production and protein kinase A (PKA) activation. Lindskog et al. report the behavioral effects of caffeine are no longer observed in mice lacking the cytosolic protein DARPP-32. This is because caffeine increases the phosphorylation of DARPP-32 on a specific threonine residue. By blocking the cAMP-PKA pathway, caffeine decreases the action of the protein phosphatase 2A on DARPP-32. Phosphorylated DARPP-32 can then further inhibit PKA activity, amplifying the shutdown of the cAMP-PKA pathway. The effect likely includes a lower level of phosphorylated target proteins of PKA that regulate nerve activity. M. Lindskog, P. Svenningsson, L. Pozzi, Y. Kim, A. A. Fienberg, J. A. Bibb B. B. Fredholm, A. C. Nairn, P. Greengard, G. Fisone, Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 418, 774-778 (2002). -- ┌─────◆ＫＫＣＩＴＹ◆─────┐KKMAN团队 全新力作 ◎◎KKBOX◎◎ │ bbs.kkcity.com.tw │知名歌手通通都有 所有新歌想听就听 └──《From:143.48.8.154 》──┘※※ 内容丰富多元的线上音乐台 ※※ --