Monoclonal antibody is the first generation of HIV vaccine, and it has failed so far, and it is expected to fail in the foreseen future. The primary challenge of using monoclonal antibody against HIV is two folds. First antibody can only target the coating proteins of free virus, which limits the number of proteins and sites antibody can target. Secondly, the two env proteins, gp41 and gp120, are highly variable such that HIV can easily mutate at antibody binding site (epitopes) and thus escape monoclonal antibody targeting. These are the two primary reasons why a lot of people have given up on making a monoclonal antibody based vaccine. for reference, Jay Berzofsky, AJ McMichael, Bruce Walker, and Rowland-Jones are good names to look up. ※ 引述《[email protected] (想找个人真心来疼)》之铭言： : 现在已经有发展单株抗体用来对抗HIV吗? : 成效又是如何? : 遇到的瓶颈又是怎样? : 有没有什麽比较大的缺点 : 恳请大家可以给点答案或资讯 : 谢谢^^~ --

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