作者lingon (风往哪里去)
看板Biology
标题Re: 请问一下有关治疗AIDS的问题
时间Thu May 4 14:14:48 2006
Monoclonal antibody is the first generation of HIV vaccine, and
it has failed so far, and it is expected to fail in the foreseen
future. The primary challenge of using monoclonal antibody
against HIV is two folds. First antibody can only target
the coating proteins of free virus, which limits the number of
proteins and sites antibody can target. Secondly, the two
env proteins, gp41 and gp120, are highly variable such that
HIV can easily mutate at antibody binding site (epitopes)
and thus escape monoclonal antibody targeting.
These are the two primary reasons why a lot of people have
given up on making a monoclonal antibody based vaccine.
for reference, Jay Berzofsky, AJ McMichael, Bruce Walker, and
Rowland-Jones are good names to look up.
※ 引述《[email protected] (想找个人真心来疼)》之铭言:
: 现在已经有发展单株抗体用来对抗HIV吗?
: 成效又是如何?
: 遇到的瓶颈又是怎样?
: 有没有什麽比较大的缺点
: 恳请大家可以给点答案或资讯
: 谢谢^^~
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※ 发信站: 批踢踢实业坊(ptt.cc)
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1F:→ apa9394:好文! 05/04 23:10