NIH funded Biomedical/Computational Postdocs Institution: Beckman Research Institute – City of Hope Cancer Center Location: L.A., California City of Hope is an NCI designated Comprehensive Cancer Center ranked top 15 in the U.S Principal Investigator: Chun-Wei David Chen, Ph.D. Assistant Professor, Department of Systems Biology Director, Division of Epigenetics and Transcriptional Engineering Contact: [email protected] Webpage: https://www.cityofhope.org/chun-wei-david-chen The Chen laboratory in Systems Biology is focused on the epigenetic mechanisms underlying the therapeutic resistance in cancers. This laboratory is skilled in high-throughput CRISPR genetic screens for de novo therapeutic target discovery. They also utilize next-generation sequencing (NGS) for epi- genomic and transcriptomic analyses (ChIPseq, ATACseq, RNAseq, etc.), and the patient-derived xenograft (PDX) models for in vivo therapeutic efficacy ass- essments. In addition, Dr. Chen’s laboratory is involved in cutting-edge technology development including high-density CRISPR protein scan, precision epigenome editing, and single-cell CRISPR/RNA-seq. The lab is well funded by several NIH (R37 MERIT, R01s, U54) and foundational (ALSF, SU2C-CRUK) awards. Publications: https://www.ncbi.nlm.nih.gov/myncbi/1rQtkueF6vPQu/bibliography/public/ Biomedical postdoc: ‧ Ph.D. degree in Bio/medical related fields (required) ‧ Mammalian cell culture, cell biology, molecular cloning, biochemistry, animal model studies Computational postdoc: ‧ Ph.D. degree in Computational Biology or Bioinformatics (required) ‧ NGS data analysis, e.g., RNAseq, ChIPseq, ATACseq, whole-genome/exome sequencing, etc. ‧ R, Python, Perl, UNIX/LINUX, etc. ‧ Protein 3D structural analysis ‧ Start date: Fall 2021 – Spring 2022 ‧ Salary: $58,240 USD/yr --

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