【职缺名称】 硕士级专任研究助理 1人 【徵才单位】 国立阳明大学 生命科学系暨基因体科学研究所 范明基老师实验室 简介: Deciphering the genetic instructions that establish the pattern of neuronal differentiation during development is one of the keys to understand the complexity of the adult brain. My laboratory has adopted developmental approaches and molecular biology tools to gain more insight about how mammalian nervous system organizes and functions through analysis of novel neural genes. By subtractive hybridization, we found that expression of Prtg, a member of immunoglobulin family, is very abundant in the E7.75 ~ E9.5 mouse neural tube but disappears after E10.5. Using the P19 cell line and chick embryo as neural differentiation models, we demonstrated that Prtg prevents precocious neuronal differentiation. We identified ERdj3 as a ligand for Prtg. Furthermore, ERdj3 prevents precocious neuronal differentiation through activation of Prtg (J. Neurosci. 30 (2010) 4428-4439). We will further investigate effects of ERdj3/Prtg in vivo and its signaling pathway. 【工作地址】 国立阳明大学 【工作内容】 分生相关实验 (PCR, in situ hybridization, etc.)、 细胞培养 【徵才条件】 生物相关研究所毕业 【薪资待遇】 比照国科会规定 硕士级35000/月 【联络方式】 意者请e-mail履历至 [email protected] 信件标题请注明〔应徵研究助理〕 【其他备注】 --

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