作者senlin (seize)
看板AfterPhD
标题Re: [新闻] 抗老化权威林育谊为何轻生?
时间Thu Nov 7 03:20:47 2013
Paper retracted today on Nature.
http://www.nature.com/nature/journal/v503/n7474/full/nature12727.html
最後一段:
"However, despite several attempts,
we were unable to obtain results
definitively supporting the major claims of the Letter, namely that p300 is
the acetyltransferase and HDAC1 is the deacetylase for PRKAA1 in cells. The
batch of polyclonal antibody against acetyl-lysine originally used is no
longer available. More definitive experiments require antibodies that
specifically recognize acetylated sites on PRKAA1, which we are developing.
Although our inability to reproduce these results does not mean our
conclusions are incorrect, we cannot say with confidence that they are
correct. Given the time that has elapsed, and our inability to reproduce the
main conclusions of the Letter, we feel obliged to retract it. "
--
※ 发信站: 批踢踢实业坊(ptt.cc)
◆ From: 184.171.85.156
1F:→ lingon:IF中心的学术世界, 跟拿着毒苹果的恶魔一样, 这篇真推不下 11/07 03:38
2F:推 oplz:think about those people who spent time and money trying 11/07 04:23
3F:→ oplz:to reproduce your results... what the hell... 11/07 04:24
4F:→ DouglasT:咳…又给puec2 猜中了 11/07 05:41
5F:→ DouglasT:所以JHU伦理委员会 用的是我在别篇讲的第三招:赖死人 11/07 05:43
6F:推 BryantKobe:看过国外的PI cell造假自己主动坦承也是活的好好的 11/07 07:08
Retraction Watch 的报导
http://goo.gl/eINbaq
同个PI在今年时曾更正一篇2006年时发表的Cell文章
这篇文章中的Daniel Yuan就是质疑Lin的结果的人
※ 编辑: senlin 来自: 184.171.85.156 (11/07 07:51)
7F:推 liuse:we were unable to obtain results跟we can't reproduce 11/07 07:40
8F:→ liuse:results是不一样的... 同一个实验 换个人做结果可能就不同 11/07 07:40
9F:→ liuse:或是你做的出来他做不出来... 而这篇就是这个情况 11/07 07:41
10F:→ liuse:不幸的是原作者已去逝,没法求证了 11/07 07:41
11F:推 nagao:推楼上 我也有那种别人做的出来但自己做不出来的状况 11/07 07:54
12F:→ nagao:已经在旁边跟他一起做了 还是他做的出来我做不出来..... 11/07 07:54
13F:→ puec2:遥想中兴Cell事件,据传被踢爆前他们实验室没人可以repeat 11/07 09:35
14F:→ puec2:老板就拼命骂+酸做不出来的人。 11/07 09:35
15F:推 oplz:见鬼..unable to obtain the same results 跟 can't 11/07 10:08
16F:→ oplz:reproduce the same results 哪里不一样? 无法再现就是无法再 11/07 10:08
17F:→ oplz:现.. 用比较好听的说法而已 11/07 10:09
18F:→ oplz:真要这样硬凹..就没有造假的实验结果 只有自己做得出来的实验 11/07 10:11
19F:→ oplz:结果.. 11/07 10:11
20F:→ puec2:人家是说抗体用完了。但是因为只有用那个抗体才做得出来, 11/07 10:14
21F:→ puec2:所以你也不能说他造假。但是没有抗体也无法重现,那就撤了吧 11/07 10:15
22F:→ puec2:感觉起来是有点凹。 11/07 10:15
23F:→ blence:如果没记错,那几支anti-acetyl是台湾genetex做的 11/07 10:42
24F:→ blence:在DM上常看到,心里觉得人家site-specific做的好顺阿 11/07 10:45
25F:→ puec2:我不是做acetylation的人,但是anti-acetyl lysine的抗体 11/07 11:07
26F:→ puec2:要怎麽做polyclonal? 11/07 11:07
27F:→ DouglasT:不可质疑的抗体 上帝的抗体 命悬一抗体啊~~ 11/07 11:21
28F:→ rickson:同意puec2,这基本上就是硬凹 11/07 12:34
29F:推 GregMaddux:我相信那个实验一有一两次结果是他们预期的 所以的确是 11/08 01:33
30F:→ GregMaddux:没造假 但再现性可能就...... 11/08 01:34
31F:→ griffey:发表nature的paper...的确对学者的吸引力太大了 11/09 00:19
32F:推 Narcissuss:要求再现性 大概10年一篇 11/09 14:27
33F:→ emitter:即使当初结果是错的,为何要动用到撤回啊? 11/10 22:05